Version 5.4
Mus musculus Gene: Ephx1
Summary
InnateDB Gene IDBG-207430.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ephx1
Gene Name epoxide hydrolase 1, microsomal
Synonyms AI195553; Eph-1; Eph1; mEH
Species Mus musculus
Ensembl Gene ENSMUSG00000038776
Encoded Proteins
IDBP-207432
epoxide hydrolase 1, microsomal
IDBP-258903
epoxide hydrolase 1, microsomal
IDBP-538764
epoxide hydrolase 1, microsomal
IDBP-535958
epoxide hydrolase 1, microsomal
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143819:
Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:180976155-181020904
Strand Reverse strand
Band H4
Transcripts
ENSMUST00000036928 ENSMUSP00000047551
ENSMUST00000111068 ENSMUSP00000106697
ENSMUST00000154133 ENSMUSP00000114363
ENSMUST00000147585 ENSMUSP00000122671
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0033961 cis-stilbene-oxide hydrolase activity
Biological Process
GO:0006725 cellular aromatic compound metabolic process
GO:0009636 response to toxic substance
GO:0014070 response to organic cyclic compound
GO:0019439 aromatic compound catabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000143819
View Gene Order
ENSBTAG00000000140
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00980
Metabolism of xenobiotics by cytochrome P450 pathway
mmu04976
Bile secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa04976
Bile secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.9075
RefSeq NM_010145
OMIM
CCDS CCDS15579
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca