InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Coq7

Summary

InnateDB Protein

IDBP-207629.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Coq7

Protein Name

demethyl-Q 7

Synonyms

clk-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032887

InnateDB Gene

IDBG-207625 (Coq7)

Protein Structure

UniProt Annotation

Function

Involved in lifespan determination in ubiquinone- independent manner. Involved in ubiquinone biosynthesis. Potential central metabolic regulator. {ECO:0000269PubMed:19478076}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:11387338}; Peripheral membrane protein {ECO:0000269PubMed:11387338}; Matrix side {ECO:0000269PubMed:11387338}. Note=Synthesized as a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off and the mature protein becomes loosely associated with the inner membrane.

Disease Associations

Tissue Specificity

Highly expressed in tissues with high energy demand such as heart, muscle, liver, and kidney. {ECO:0000269PubMed:11511092}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046872	metal ion binding

Biological Process

GO:0001306	age-dependent response to oxidative stress
GO:0001701	in utero embryonic development
GO:0001841	neural tube formation
GO:0006744	ubiquinone biosynthetic process
GO:0006979	response to oxidative stress
GO:0008340	determination of adult lifespan
GO:0022008	neurogenesis
GO:0022904	respiratory electron transport chain
GO:0034599	cellular response to oxidative stress
GO:0042775	mitochondrial ATP synthesis coupled electron transport
GO:0055114	oxidation-reduction process
GO:0070584	mitochondrion morphogenesis