InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hao1

Summary

InnateDB Protein

IDBP-207632.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hao1

Protein Name

hydroxyacid oxidase 1, liver

Synonyms

GOX; Gox1; Hao-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028704

InnateDB Gene

IDBG-207630 (Hao1)

Protein Structure

UniProt Annotation

Function

Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2- hydroxy octanoate (By similarity). {ECO:0000250}.

Subcellular Localization

Peroxisome.

Disease Associations

Tissue Specificity

Liver. {ECO:0000269PubMed:9891009}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003973	(S)-2-hydroxy-acid oxidase activity
GO:0005102	receptor binding
GO:0008891	glycolate oxidase activity
GO:0010181	FMN binding
GO:0015930	glutamate synthase activity
GO:0016491	oxidoreductase activity
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors
GO:0052852	very-long-chain-(S)-2-hydroxy-acid oxidase activity
GO:0052853	long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
GO:0052854	medium-chain-(S)-2-hydroxy-acid oxidase activity

Biological Process

GO:0001561	fatty acid alpha-oxidation
GO:0006537	glutamate biosynthetic process
GO:0006979	response to oxidative stress
GO:0046296	glycolate catabolic process
GO:0055114	oxidation-reduction process