Mus musculus Gene: Hao1
Summary
InnateDB Gene IDBG-207630.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hao1
Gene Name hydroxyacid oxidase 1, liver
Synonyms GOX; Gox1; Hao-1;
Species Mus musculus
Ensembl Gene ENSMUSG00000027261
Encoded Proteins
hydroxyacid oxidase 1, liver
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101323:
This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:134497361-134554368
Strand Reverse strand
Band F2
Transcripts
ENSMUST00000028704 ENSMUSP00000028704
ENSMUST00000140794
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003973 (S)-2-hydroxy-acid oxidase activity
GO:0005102 receptor binding
GO:0008891 glycolate oxidase activity
GO:0010181 FMN binding
GO:0015930 glutamate synthase activity
GO:0016491 oxidoreductase activity
GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors
GO:0052852 very-long-chain-(S)-2-hydroxy-acid oxidase activity
GO:0052853 long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
GO:0052854 medium-chain-(S)-2-hydroxy-acid oxidase activity
Biological Process
GO:0001561 fatty acid alpha-oxidation
GO:0006537 glutamate biosynthetic process
GO:0006979 response to oxidative stress
GO:0046296 glycolate catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005777 peroxisome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Glyoxylate metabolism pathway
KEGG
Glyoxylate and dicarboxylate metabolism pathway
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of amino acids and derivatives pathway
Glyoxylate metabolism pathway
Metabolism pathway
KEGG
Glyoxylate and dicarboxylate metabolism pathway
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9WU19
TrEMBL Q3UEE8
UniProt Splice Variant
Entrez Gene 15112
UniGene Mm.26634
RefSeq NM_010403
OMIM
CCDS CCDS16783
HPRD
IMGT
MGI ID MGI:96011
MGI Symbol Hao1
EMBL AF104312 AK149565 BC119535 BC119536 CH466519
GenPept AAD25332 AAI19536 AAI19537 BAE28963 EDL28373
RNA Seq Atlas 15112