InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hao1

Summary

InnateDB Gene

IDBG-207630.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hao1

Gene Name

hydroxyacid oxidase 1, liver

Synonyms

GOX; Gox1; Hao-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027261

Encoded Proteins

IDBP-207632

hydroxyacid oxidase 1, liver

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101323:
This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:134497361-134554368

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028704	ENSMUSP00000028704
ENSMUST00000140794

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003973	(S)-2-hydroxy-acid oxidase activity
GO:0005102	receptor binding
GO:0008891	glycolate oxidase activity
GO:0010181	FMN binding
GO:0015930	glutamate synthase activity
GO:0016491	oxidoreductase activity
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors
GO:0052852	very-long-chain-(S)-2-hydroxy-acid oxidase activity
GO:0052853	long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
GO:0052854	medium-chain-(S)-2-hydroxy-acid oxidase activity

Biological Process

GO:0001561	fatty acid alpha-oxidation
GO:0006537	glutamate biosynthetic process
GO:0006979	response to oxidative stress
GO:0046296	glycolate catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005777

peroxisome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000101323

View Gene Order

ENSBTAG00000019811

Not yet available

Pathways

NETPATH

REACTOME

REACT_188937

Metabolism pathway

REACT_232845

Metabolism of amino acids and derivatives pathway

REACT_261828

Glyoxylate metabolism pathway

KEGG

mmu00630

Glyoxylate and dicarboxylate metabolism pathway

mmu04146

Peroxisome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_16925

Glyoxylate metabolism pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00630

Glyoxylate and dicarboxylate metabolism pathway

hsa04146

Peroxisome pathway

INOH

PID NCI

Cross-References

SwissProt

Q9WU19

TrEMBL

Q3UEE8

UniProt Splice Variant

Entrez Gene

15112

UniGene

Mm.26634

RefSeq

NM_010403

OMIM

CCDS

CCDS16783

HPRD

IMGT

MGI ID

MGI:96011

MGI Symbol

Hao1

EMBL

AF104312 AK149565 BC119535 BC119536 CH466519

GenPept

AAD25332 AAI19536 AAI19537 BAE28963 EDL28373

RNA Seq Atlas

15112