Version 5.4
Mus musculus Protein: Arpc1b
Summary
InnateDB Protein IDBP-208515.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arpc1b
Protein Name actin related protein 2/3 complex, subunit 1B
Synonyms 41kDa; AA408064; AA408534; AA571392; AF007010; AW208418; L72; p41-ARC; SOP2Hs;
Species Mus musculus
Ensembl Protein ENSMUSP00000082822
InnateDB Gene IDBG-208513 (Arpc1b)
Protein Structure
UniProt Annotation
Function Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0030833 regulation of actin filament polymerization
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1343142
InterPro IPR001680 WD40 repeat
IPR017383 ARP2/3 complex, 41kDa subunit (p41-arc)
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF PIRSF038093
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WV32
PhosphoSite PhosphoSite-Q9WV32
TrEMBL Q91Z25
UniProt Splice Variant
Entrez Gene 434782
UniGene Mm.470460
RefSeq NP_075631
MGI ID
MGI Symbol Arpc1b
OMIM
CCDS CCDS19856
HPRD
IMGT
EMBL AC110556 AF162768 AK002274 AK005378 AK147731 AK148145 AK159371 AK167978 AK168774 AK172124 BC003441 BC010275 BC092051 CH466529
GenPept AAD43352 AAH03441 AAH10275 AAH92051 BAB21980 BAB23985 BAE28101 BAE28373 BAE35028 BAE39970 BAE40610 BAE42835 EDL19001 EDL19002

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca