Version 5.4
Mus musculus Protein: Hhat
Summary
InnateDB Protein IDBP-208981.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hhat
Protein Name hedgehog acyltransferase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000046686
InnateDB Gene IDBG-208979 (Hhat)
Protein Structure
UniProt Annotation
Function Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling during limb development. May bind GTP. {ECO:0000269PubMed:15075292}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:15075292, ECO:0000269PubMed:18081866}; Multi- pass membrane protein {ECO:0000269PubMed:15075292, ECO:0000269PubMed:18081866}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005525 GTP binding
GO:0016409 palmitoyltransferase activity
Biological Process
GO:0007224 smoothened signaling pathway
GO:0007275 multicellular organismal development
GO:0018345 protein palmitoylation
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2444681
InterPro IPR004299 Membrane bound O-acyl transferase, MBOAT
PFAM PF03062
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BMT9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 226861
UniGene Mm.418624
RefSeq NP_659130
MGI ID
MGI Symbol Hhat
OMIM
CCDS CCDS15628
HPRD
IMGT
EMBL AC105325 AC115917 AK028230 AK172126 AL365317 BC008159
GenPept AAH08159 BAC25829 BAE42837 CAO82115

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca