Version 5.4
Mus musculus Gene: Hhat
Summary
InnateDB Gene IDBG-208979.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hhat
Gene Name hedgehog acyltransferase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000037375
Encoded Proteins
IDBP-208981
hedgehog acyltransferase
IDBP-538779
hedgehog acyltransferase
IDBP-532274
hedgehog acyltransferase
IDBP-538235
hedgehog acyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000054392:
'Skinny hedgehog' (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of 'hedgehog' (see MIM 600725).[supplied by OMIM, Jul 2002]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:192512828-192771213
Strand Reverse strand
Band H6
Transcripts
ENSMUST00000044190 ENSMUSP00000046686
ENSMUST00000128619 ENSMUSP00000120479
ENSMUST00000154755 ENSMUSP00000121849
ENSMUST00000123721
ENSMUST00000154203 ENSMUSP00000119907
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005525 GTP binding
GO:0016409 palmitoyltransferase activity
Biological Process
GO:0007224 smoothened signaling pathway
GO:0007275 multicellular organismal development
GO:0018345 protein palmitoylation
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000054392
View Gene Order
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_233316
Hedgehog ligand biogenesis pathway
REACT_248271
Processing-defective Hh variants abrogate ligand secretion pathway
REACT_232469
Hh ligand biogenesis disease pathway
REACT_250064
Signaling by Hedgehog pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
INOH website
Hedgehog signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_10
Hedgehog pathway
REACTOME
REACT_228190
Processing-defective Hh variants abrogate ligand secretion pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_111102
Signal Transduction pathway
REACT_228209
Hh ligand biogenesis disease pathway
REACT_228111
Hedgehog ligand biogenesis pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
Hedgehog signaling pathway pathway
PID NCI
hedgehog_2pathway
Signaling events mediated by the Hedgehog family
Cross-References
SwissProt Q8BMT9
TrEMBL B1ANR9 Q8BWF5
UniProt Splice Variant
Entrez Gene 226861
UniGene Mm.145857 Mm.418624
RefSeq NM_144881 XM_006497252
OMIM
CCDS CCDS15628
HPRD
IMGT
MGI ID MGI:2444681
MGI Symbol Hhat
EMBL AC105325 AC115917 AK028230 AK052669 AK172126 AL365317 BC008159
GenPept AAH08159 BAC25829 BAC35090 BAE42837 CAO82115
RNA Seq Atlas 226861

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca