Version 5.4
Mus musculus Protein: Flt1
Summary
InnateDB Protein IDBP-209102.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Flt1
Protein Name FMS-like tyrosine kinase 1
Synonyms AI323757; Flt-1; sFlt1; VEGFR-1; VEGFR1;
Species Mus musculus
Ensembl Protein ENSMUSP00000031652
InnateDB Gene IDBG-209098 (Flt1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0042802 identical protein binding
Biological Process
GO:0001525 angiogenesis
GO:0001569 patterning of blood vessels
GO:0002040 sprouting angiogenesis
GO:0006468 protein phosphorylation
GO:0016477 cell migration
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0048010 vascular endothelial growth factor receptor signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID MGI:95558
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR009135 Vascular endothelial growth factor receptor 1 (VEGFR1)
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
PFAM PF07679
PF07686
PF00047
PRINTS PR01833
PIRSF
SMART SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9DAV2
UniProt Splice Variant
Entrez Gene 14254
UniGene Mm.401078
RefSeq
MGI ID
MGI Symbol Flt1
OMIM
CCDS
HPRD
IMGT
EMBL AC122299 AC131730 AK005502 AK013236
GenPept BAB24084 BAB28733

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca