InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rfc3

Summary

InnateDB Protein

IDBP-209722.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rfc3

Protein Name

replication factor C (activator 1) 3

Synonyms

2810416I22Rik; 38kDa; AU022547; Recc3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039621

InnateDB Gene

IDBG-209720 (Rfc3)

Protein Structure

UniProt Annotation

Function

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0046683	response to organophosphorus

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1916513

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00004
PF07724
PF13304

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R323