InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mylk2

Summary

InnateDB Protein

IDBP-209916.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mylk2

Protein Name

myosin, light polypeptide kinase 2, skeletal muscle

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028970

InnateDB Gene

IDBG-209914 (Mylk2)

Protein Structure

UniProt Annotation

Function

Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N- terminus of a myosin light chain (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004687	myosin light chain kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006941	striated muscle contraction
GO:0007274	neuromuscular synaptic transmission
GO:0010628	positive regulation of gene expression
GO:0014816	satellite cell differentiation
GO:0018107	peptidyl-threonine phosphorylation
GO:0032971	regulation of muscle filament sliding
GO:0035914	skeletal muscle cell differentiation
GO:0046777	protein autophosphorylation
GO:0055007	cardiac muscle cell differentiation
GO:0055008	cardiac muscle tissue morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:2139434

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt