InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HACL1

Summary

InnateDB Protein

IDBP-21015.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HACL1

Protein Name

2-hydroxyacyl-CoA lyase 1

Synonyms

2-HPCL; HPCL; HPCL2; PHYH2;

Species

Homo sapiens

Ensembl Protein

ENSP00000323811

InnateDB Gene

IDBG-21011 (HACL1)

Protein Structure

UniProt Annotation

Function

Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.

Subcellular Localization

Peroxisome.

Disease Associations

Tissue Specificity

Expressed in high levels in liver, also expressed in kidney, heart and skeletal muscle. {ECO:0000269PubMed:10468558}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	9 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0005102	receptor binding
GO:0016829	lyase activity
GO:0016830	carbon-carbon lyase activity
GO:0030976	thiamine pyrophosphate binding
GO:0042802	identical protein binding
GO:0048037	cofactor binding

Biological Process

GO:0001561	fatty acid alpha-oxidation
GO:0006629	lipid metabolic process
GO:0019385	methanogenesis, from acetate
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0051259	protein oligomerization

Cellular Component

GO:0005777	peroxisome
GO:0005782	peroxisomal matrix

Protein Structure and Domains

PDB ID

InterPro

IPR003704 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit
IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding
IPR012000 Thiamine pyrophosphate enzyme, central domain
IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain
IPR029035 DHS-like NAD/FAD-binding domain
IPR029061 Thiamin diphosphate-binding fold

PFAM

PF02552
PF02775
PF00205
PF02776

PRINTS

PIRSF

PIRSF006035

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UJ83