Homo sapiens Gene: HACL1
Summary
InnateDB Gene IDBG-21011.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HACL1
Gene Name 2-hydroxyacyl-CoA lyase 1
Synonyms 2-HPCL; HPCL; HPCL2; PHYH2;
Species Homo sapiens
Ensembl Gene ENSG00000131373
Encoded Proteins
2-hydroxyacyl-CoA lyase 1
2-hydroxyacyl-CoA lyase 1
2-hydroxyacyl-CoA lyase 1
2-hydroxyacyl-CoA lyase 1
2-hydroxyacyl-CoA lyase 1
2-hydroxyacyl-CoA lyase 1
2-hydroxyacyl-CoA lyase 1
2-hydroxyacyl-CoA lyase 1
2-hydroxyacyl-CoA lyase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:15560704-15601831
Strand Reverse strand
Band p25.1
Transcripts
ENST00000321169 ENSP00000323811
ENST00000383779 ENSP00000373289
ENST00000456194 ENSP00000390699
ENST00000457447 ENSP00000404883
ENST00000451445 ENSP00000403656
ENST00000435217 ENSP00000395278
ENST00000422591 ENSP00000392796
ENST00000421993 ENSP00000391393
ENST00000414979 ENSP00000395352
ENST00000469454
ENST00000460907
ENST00000472857
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 9 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0005102 receptor binding
GO:0016829 lyase activity
GO:0016830 carbon-carbon lyase activity
GO:0030976 thiamine pyrophosphate binding
GO:0042802 identical protein binding
GO:0048037 cofactor binding
Biological Process
GO:0001561 fatty acid alpha-oxidation
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0019385 methanogenesis, from acetate
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0051259 protein oligomerization
Cellular Component
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Peroxisomal lipid metabolism pathway
Alpha-oxidation of phytanate pathway
Metabolism pathway
KEGG
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UJ83
TrEMBL
UniProt Splice Variant
Entrez Gene 26061
UniGene Hs.63290
RefSeq NM_001284413 NM_001284415 NM_001284416 NM_012260
HUGO HGNC:17856
OMIM 604300
CCDS CCDS68360 CCDS2627 CCDS68361 CCDS68362
HPRD 09183
IMGT
EMBL AC027129 AF161397 AJ131753 AK301546 AK301990 BC001627
GenPept AAF28957 AAH01627 BAG63043 BAG63397 CAB60200
RNA Seq Atlas 26061