InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Raly

Summary

InnateDB Protein

IDBP-210487.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Raly

Protein Name

hnRNP-associated with lethal yellow

Synonyms

AI663842; Merc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058105

InnateDB Gene

IDBG-210483 (Raly)

Protein Structure

UniProt Annotation

Function

Probable-RNA binding protein. Could be a heterogeneous nuclear ribonucleoprotein (hnRNP). May be involved in pre-mRNA splicing (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Note=Defects in Raly are the cause of lethal yellow mutation (A(y)), a dominant allele that cause embryonic lethality when homozygous, and pleiotropic effects when heterozygous, including yellow pelage, obesity, non-insulin dependent diabetes and increased tumor susceptibility. A(y) is due to a 170 kb deletion that removes all but the promoter and non-coding first exon of Raly and links them to the ASIP/Agouti gene.

Tissue Specificity

Widely expressed. Expressed in brain, testis, lung, spleen and kidney. Weakly expressed in liver. {ECO:0000269PubMed:8319910}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding