InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Med24

Summary

InnateDB Protein

IDBP-210638.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Med24

Protein Name

mediator complex subunit 24

Synonyms

911GSE; AU040102; AW547152; D11Ertd307e; DRIP100; Gse2; Pparb2; Pparbp2; R75526; Thrap4; Trap100;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000017354

InnateDB Gene

IDBG-210636 (Med24)

Protein Structure

UniProt Annotation

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for basal and activator-dependent transcription. {ECO:0000250, ECO:0000269PubMed:10406464, ECO:0000269PubMed:12093747}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in the adrenal gland, brain, epididymis, heart, kidney, liver, ovary, pancreas, prostate, skeletal muscle, small intestine, spleen, stomach, testis and thymus. {ECO:0000269PubMed:10406464, ECO:0000269PubMed:12093747}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	58 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0004872	receptor activity
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0016573	histone acetylation
GO:0019827	stem cell maintenance
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051291	protein heterooligomerization