InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SKIV2L2

Summary

InnateDB Protein

IDBP-21085.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SKIV2L2

Protein Name

superkiller viralicidic activity 2-like 2 (S. cerevisiae)

Synonyms

Dob1; fSAP118; KIAA0052; Mtr4;

Species

Homo sapiens

Ensembl Protein

ENSP00000230640

InnateDB Gene

IDBG-21081 (SKIV2L2)

Protein Structure

UniProt Annotation

Function

May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA. {ECO:0000269PubMed:17412707}.

Subcellular Localization

Nucleus, nucleoplasm. Nucleus, nucleolus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.

Experimentally validated
Total	45 [view]
Protein-Protein	45 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0000460	maturation of 5.8S rRNA

Cellular Component

GO:0000178	exosome (RNase complex)
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DEAD/DEAH box helicase domain
IPR012961 DSH, C-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR016438 RNA helicase, ATP-dependent, SK12/DOB1
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270
PF08148

PRINTS

PIRSF

PIRSF005198

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt