Version 5.4
Mus musculus Protein: Bub3
Summary
InnateDB Protein IDBP-211016.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bub3
Protein Name budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae)
Synonyms AU019800; AU021329; AU043350; AW146323; C78067;
Species Mus musculus
Ensembl Protein ENSMUSP00000081547
InnateDB Gene IDBG-211014 (Bub3)
Protein Structure
UniProt Annotation
Function Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1 (By similarity). Regulates chromosome segregation during oocyte meiosis. {ECO:0000250, ECO:0000269PubMed:19888327}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000269PubMed:19888327}. Note=Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI- AI) transition. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0007059 chromosome segregation
GO:0007126 meiotic nuclear division
GO:0008608 attachment of spindle microtubules to kinetochore
GO:0051983 regulation of chromosome segregation
GO:0071173 spindle assembly checkpoint
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1343463
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PRINTS PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WVA3
PhosphoSite PhosphoSite-Q9WVA3
TrEMBL Q8BH42
UniProt Splice Variant
Entrez Gene 12237
UniGene Mm.419467
RefSeq NP_033904
MGI ID
MGI Symbol Bub3
OMIM
CCDS CCDS40160
HPRD
IMGT
EMBL AF149822 AK039977 AK079742 AK088534 BC025089 U67327
GenPept AAB39606 AAD38038 AAH25089 BAC30489 BAC37738 BAC40409

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca