InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Samhd1

Summary

InnateDB Protein

IDBP-211116.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Samhd1

Protein Name

SAM domain and HD domain, 1

Synonyms

E330031J07Rik; Mg11;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059717

InnateDB Gene

IDBG-211114 (Samhd1)

Protein Structure

UniProt Annotation

Function

Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0008270	zinc ion binding
GO:0008832	dGTPase activity
GO:0032567	dGTP binding
GO:0046872	metal ion binding

Biological Process

GO:0006203	dGTP catabolic process
GO:0008152	metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045088	regulation of innate immune response
GO:0046061	dATP catabolic process
GO:0051289	protein homotetramerization
GO:0051607	defense response to virus

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:1927468

InterPro

IPR001660 Sterile alpha motif domain
IPR003607 HD/PDEase domain
IPR006674 HD domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF01966
PF13023
PF07647
PF00536

PRINTS

PIRSF

SMART

SM00454
SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q60710