Version 5.4
Mus musculus Gene: Samhd1
Summary
InnateDB Gene IDBG-211114.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Samhd1
Gene Name SAM domain and HD domain, 1
Synonyms E330031J07Rik; Mg11
Species Mus musculus
Ensembl Gene ENSMUSG00000027639
Encoded Proteins
IDBP-211116
SAM domain and HD domain, 1
IDBP-211118
SAM domain and HD domain, 1
IDBP-262158
SAM domain and HD domain, 1
IDBP-542002
SAM domain and HD domain, 1
IDBP-532165
SAM domain and HD domain, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21720370
Samhd11 is specifically targeted for degradation by human immunodeficiency virus 1 (HIV-1) viral protein VPX, and mutations in SAMHD11 causes Aicardi-Goutieres syndrome, which mimics symptoms of congenital viral infection. (Demonstrated in human)
PMID 21613998
Samhd1 is expressed in dendritic and myeloid cells and acts as an anti-retroviral protein that inhibits the early stages of the viral life cycle. Silencing of SAMHD1 leads to significant accumulation of human immunodeficiency virus 1 (HIV-1) DNA in infected cells. (Demonstrated in human)
PMID 22327569
Samhd1 inhibits HIV replication by depleting intracellular dNTPs, which are required for viral reverse transcriptase to synthesize viral DNA. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
PMID 21720370
[Homo sapiens] SAMHD1 is specifically targeted for degradation by human immunodeficiency virus 1 (HIV-1) viral protein VPX, and mutations in SAMHD1 causes Aicardi-Goutieres syndrome, which mimics symptoms of congenital viral infection.
PMID 21613998
[Homo sapiens] SAMHD1 is expressed in dendritic and myeloid cells and acts as an anti-retroviral protein that inhibits the early stages of the viral life cycle. Silencing of SAMHD1 leads to significant accumulation of human immunodeficiency virus 1 (HIV-1) DNA in infected cells.
PMID 22327569
[Homo sapiens] SAMHD1 inhibits HIV replication by depleting intracellular dNTPs, which are required for viral reverse transcriptase to synthesize viral DNA.
PMID 24753578
[Homo sapiens] Full activation of SAMHD1 involves ordered binding of GTP and substrate dNTPs to activator and substrate sites on the enzyme.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101347:
This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:157097533-157135265
Strand Reverse strand
Band H1
Transcripts
ENSMUST00000057725 ENSMUSP00000059717
ENSMUST00000088523 ENSMUSP00000085880
ENSMUST00000109549 ENSMUSP00000105176
ENSMUST00000123932 ENSMUSP00000124599
ENSMUST00000139263 ENSMUSP00000124935
ENSMUST00000160213
ENSMUST00000139149
ENSMUST00000142508
ENSMUST00000149313
ENSMUST00000152866
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
GO:0008270 zinc ion binding
GO:0008832 dGTPase activity
GO:0032567 dGTP binding
GO:0046872 metal ion binding
Biological Process
GO:0006203 dGTP catabolic process
GO:0008152 metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045088 regulation of innate immune response
GO:0046061 dATP catabolic process
GO:0051289 protein homotetramerization
GO:0051607 defense response to virus
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101347
View Gene Order
ENSBTAG00000022007
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.248478 Mm.468781
RefSeq NM_001139520 NM_018851
OMIM
CCDS CCDS16973 CCDS50783
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca