InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctbp2

Summary

InnateDB Protein

IDBP-211195.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctbp2

Protein Name

C-terminal binding protein 2

Synonyms

AA407280; D7Ertd45e; Gtrgeo6; Ribeye;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033269

InnateDB Gene

IDBG-211193 (Ctbp2)

Protein Structure

UniProt Annotation

Function

Corepressor targeting diverse transcription regulators. Isoform 2 probably acts as a scaffold for specialized synapses (By similarity). Functions in brown adipose tissue (BAT) differentiation. {ECO:0000250, ECO:0000269PubMed:18483224}.

Subcellular Localization

Nucleus {ECO:0000305}. Cell junction, synapse {ECO:0000250}.

Disease Associations

Tissue Specificity

Found in all tissues except spleen and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	56 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287	NAD binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0008152	metabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050872	white fat cell differentiation
GO:0055114	oxidation-reduction process