InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Krt17

Summary

InnateDB Protein

IDBP-211309.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Krt17

Protein Name

keratin 17

Synonyms

K17; Krt1-17;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079699

InnateDB Gene

IDBG-211307 (Krt17)

Protein Structure

UniProt Annotation

Function

May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16702408, ECO:0000269PubMed:16710422}.

Disease Associations

Tissue Specificity

Expressed strongly in outer root sheath and medulla region of hair follicle and in the early differentiating epithelial cells (trichocytes) within the hair bulb region. Weak expression in the matrix cells of hair bulb. Also present in the sweat gland within the skin, vibrissae follicle, salivary gland, tooth and thymus. {ECO:0000269PubMed:10844551, ECO:0000269PubMed:14714564, ECO:0000269PubMed:2433272}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0032395	MHC class II receptor activity
GO:0042289	MHC class II protein binding

Biological Process

GO:0002009	morphogenesis of an epithelium
GO:0007165	signal transduction
GO:0030307	positive regulation of cell growth
GO:0031424	keratinization
GO:0045109	intermediate filament organization
GO:0045727	positive regulation of translation
GO:0051798	positive regulation of hair follicle development