InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Glrx3

Summary

InnateDB Protein

IDBP-211433.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Glrx3

Protein Name

glutaredoxin 3

Synonyms

PICOT; Txnl2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066621

InnateDB Gene

IDBG-211431 (Glrx3)

Protein Structure

UniProt Annotation

Function

Crucial regulator of cellular iron homeostasis and hemoglobin maturation (By similarity). Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. May play a role in regulating the function of the thioredoxin system. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. Has an essential function in embryogenesis. {ECO:0000250, ECO:0000269PubMed:16809552, ECO:0000269PubMed:18258855, ECO:0000269PubMed:18929570}.

Subcellular Localization

Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC- theta translocate to a more extended submembrane area (By similarity). In the Z line, found associated with CSRP3. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0015035	protein disulfide oxidoreductase activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0007067	mitotic nuclear division
GO:0010614	negative regulation of cardiac muscle hypertrophy
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005681	spliceosomal complex
GO:0005938	cell cortex
GO:0030018	Z disc
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1353653

InterPro

IPR002109 Glutaredoxin
IPR004123 mRNA splicing factor, thioredoxin-like U5 snRNP
IPR004480 Monothiol glutaredoxin-related
IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
IPR024253 Phosducin, thioredoxin-like domain

PFAM