InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Paox

Summary

InnateDB Protein

IDBP-211673.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Paox

Protein Name

polyamine oxidase (exo-N4-amino)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026537

InnateDB Gene

IDBG-211671 (Paox)

Protein Structure

UniProt Annotation

Function

Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)- acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.

Subcellular Localization

Peroxisome {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed at different developmental stages. Expressed at high level in the liver and the stomach, expressed at lower level in heart, spleen, thymus, small intestine, muscle, pancreas, uterus, and breast and expressed at very low level in brain, kidney, lung, testis, skin, adrenal gland and prostate gland. {ECO:0000269PubMed:12660232}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0016491	oxidoreductase activity
GO:0046592	polyamine oxidase activity
GO:0052899	N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
GO:0052901	spermine:oxygen oxidoreductase (spermidine-forming) activity
GO:0052902	spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity
GO:0052903	N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
GO:0052904	N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity

Biological Process

GO:0006598	polyamine catabolic process
GO:0009446	putrescine biosynthetic process
GO:0009447	putrescine catabolic process
GO:0046203	spermidine catabolic process
GO:0046208	spermine catabolic process
GO:0055114	oxidation-reduction process
GO:1901307	positive regulation of spermidine biosynthetic process