InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPAP2A

Summary

InnateDB Protein

IDBP-21173.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPAP2A

Protein Name

phosphatidic acid phosphatase type 2A

Synonyms

LLP1a; LPP1; PAP-2a; PAP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000302229

InnateDB Gene

IDBG-21171 (PPAP2A)

Protein Structure

UniProt Annotation

Function

Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma. {ECO:0000269PubMed:12909631}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Ubiquitously expressed with highest expression found in prostate. Isoform 1 is predominant in kidney, lung, placenta and liver. Isoform 2 is predominant in heart and pancreas. Found to be down-regulated in colon adenocarcinomas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0008195	phosphatidate phosphatase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006665	sphingolipid metabolic process
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0008354	germ cell migration
GO:0019216	regulation of lipid metabolic process
GO:0030148	sphingolipid biosynthetic process
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0044281	small molecule metabolic process
GO:0046839	phospholipid dephosphorylation