Version 5.4
Homo sapiens Gene: PPAP2A
Summary
InnateDB Gene IDBG-21171.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPAP2A
Gene Name phosphatidic acid phosphatase type 2A
Synonyms LLP1a; LPP1; PAP-2a; PAP2
Species Homo sapiens
Ensembl Gene ENSG00000067113
Encoded Proteins
IDBP-21173
phosphatidic acid phosphatase type 2A
IDBP-21175
phosphatidic acid phosphatase type 2A
IDBP-473963
phosphatidic acid phosphatase type 2A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of this gene is found to be regulated by androgen in a prostatic adenocarcinoma cell line. At least two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:55424854-55535050
Strand Reverse strand
Band q11.2
Transcripts
ENST00000307259 ENSP00000302229
ENST00000264775 ENSP00000264775
ENST00000520263
ENST00000509667 ENSP00000425052
ENST00000515132
ENST00000502907
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008195 phosphatidate phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0006629 lipid metabolic process
GO:0006665 sphingolipid metabolic process
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0008285 negative regulation of cell proliferation
GO:0008354 germ cell migration
GO:0016311 dephosphorylation
GO:0019216 regulation of lipid metabolic process
GO:0030148 sphingolipid biosynthetic process
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030521 androgen receptor signaling pathway
GO:0044281 small molecule metabolic process
GO:0046839 phospholipid dephosphorylation
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021759
View Gene Order
ENSBTAG00000010526
Not yet available
Pathways
NETPATH
REACTOME
REACT_115810
Sphingolipid de novo biosynthesis pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
hsa00564
Glycerophospholipid metabolism pathway
hsa00565
Ether lipid metabolism pathway
hsa00561
Glycerolipid metabolism pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04975
Fat digestion and absorption pathway
INOH
PID NCI
p73pathway
p73 transcription factor network
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_003711 NM_176895
HUGO
OMIM
CCDS CCDS34159 CCDS34160
HPRD 06178
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca