InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sigirr

Summary

InnateDB Protein

IDBP-211979.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sigirr

Protein Name

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

Synonyms

AI256711; TIR8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095571

InnateDB Gene

IDBG-211977 (Sigirr)

Protein Structure

UniProt Annotation

Function

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed at high levels in kidney, and at moderate levels in colon, small intestine, lung, spleen and liver. Not expressed in brain and muscle. Expressed at high levels in epithelial cells, at moderate levels in splenocytes, and at low or undetectable levels in fibroblasts or endothelial cells. Expressed in mucosal and dendritic cells. {ECO:0000269PubMed:12925853, ECO:0000269PubMed:14993616, ECO:0000269PubMed:21077278}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001960	negative regulation of cytokine-mediated signaling pathway
GO:0006953	acute-phase response
GO:0007165	signal transduction
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045079	negative regulation of chemokine biosynthetic process