InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sigirr

Summary

InnateDB Gene

IDBG-211977.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sigirr

Gene Name

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

Synonyms

AI256711; TIR8

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025494

Encoded Proteins

IDBP-211979

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 12925853

[Homo sapiens] SIGIRR is a negative modulator of TLR-IL-1R signalling where it binds to the TLR-IL-1R signalling components in a ligand-dependent way.

PMID 20060329

[Homo sapiens] SIGIRR controls Th17 cell expansion and effector function through the IL-1-induced mTOR signalling pathway.

PMID 20130217

[Homo sapiens] SIGIRR regulates innate responses in differentiated human intestinal epithelial cells (IECs), modulating epithelial involvement in infectious and inflammatory bowel diseases.

PMID 20364327

[Homo sapiens] SIGIRR can inhibit Toll-like receptor (TLR) 4, 5, and 9-mediated immune responses by attenuating production of the inflammatory mediators IL-6 and TNF-alpha and this attenuation was not the result of decreased expression of TLR4, 5 or 9, but rather a sequestration of MYD88 to the TLRs.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185187:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:141091175-141100546

Strand

Reverse strand

Band

Transcripts

ENSMUST00000097958

ENSMUSP00000095571

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001960	negative regulation of cytokine-mediated signaling pathway
GO:0006953	acute-phase response
GO:0007165	signal transduction
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045079	negative regulation of chemokine biosynthetic process