InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrdd

Summary

InnateDB Protein

IDBP-212223.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrdd

Protein Name

leucine-rich and death domain containing

Synonyms

1200011D09Rik; AU042446; Lrdd; Pidd;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026580

InnateDB Gene

IDBG-212221 (Lrdd)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007165	signal transduction
GO:0043066	negative regulation of apoptotic process
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001235	positive regulation of apoptotic signaling pathway
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus

Protein Structure and Domains

PDB ID

MGI:1889507

InterPro

IPR000488 Death domain
IPR000906 ZU5
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR011029 Death-like domain
IPR019502 Peptidase S68, pidd

PFAM

PF00531
PF00791
PF00560
PF13504
PF13855
PF10461

PRINTS

PIRSF

SMART

SM00005
SM00218
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ERV7