InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Igf2

Summary

InnateDB Protein

IDBP-212627.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Igf2

Protein Name

insulin-like growth factor 2

Synonyms

AL033362; Igf-2; Igf-II; M6pr; Mpr; Peg2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000033

InnateDB Gene

IDBG-212623 (Igf2)

Protein Structure

UniProt Annotation

Function

The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005158	insulin receptor binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0030546	receptor activator activity
GO:0043539	protein serine/threonine kinase activator activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0001934	positive regulation of protein phosphorylation
GO:0006006	glucose metabolic process
GO:0007565	female pregnancy
GO:0007613	memory
GO:0009314	response to radiation
GO:0009887	organ morphogenesis
GO:0031017	exocrine pancreas development
GO:0031667	response to nutrient levels
GO:0032355	response to estradiol
GO:0035094	response to nicotine
GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0042060	wound healing
GO:0042104	positive regulation of activated T cell proliferation
GO:0042493	response to drug
GO:0043085	positive regulation of catalytic activity
GO:0043410	positive regulation of MAPK cascade
GO:0045471	response to ethanol
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0045840	positive regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046628	positive regulation of insulin receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051146	striated muscle cell differentiation
GO:0051781	positive regulation of cell division
GO:0051897	positive regulation of protein kinase B signaling
GO:0071260	cellular response to mechanical stimulus
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0090031	positive regulation of steroid hormone biosynthetic process
GO:2000273	positive regulation of receptor activity
GO:2000467	positive regulation of glycogen (starch) synthase activity

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

MGI:96434

InterPro

IPR013576 Insulin-like growth factor II E-peptide, C-terminal
IPR016179 Insulin-like
IPR022334 Insulin-like growth factor II
IPR022350 Insulin-like growth factor
IPR022352 Insulin family

PFAM

PF08365
PF00049

PRINTS

PR02006
PR02002
PR00276

PIRSF

SMART

SM00078

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt