Version 5.4
Mus musculus Gene: Igf2
Summary
InnateDB Gene IDBG-212623.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Igf2
Gene Name insulin-like growth factor 2
Synonyms AL033362; Igf-2; Igf-II; M6pr; Mpr; Peg2
Species Mus musculus
Ensembl Gene ENSMUSG00000048583
Encoded Proteins
IDBP-212627
insulin-like growth factor 2
IDBP-212629
insulin-like growth factor 2
IDBP-269819
insulin-like growth factor 2
IDBP-269821
insulin-like growth factor 2
IDBP-400119
insulin-like growth factor 2
IDBP-542006
insulin-like growth factor 2
IDBP-722391
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167244:
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5\' region overlaps the INS gene and the 3\' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:142650766-142666816
Strand Reverse strand
Band F5
Transcripts
ENSMUST00000000033 ENSMUSP00000000033
ENSMUST00000097936 ENSMUSP00000095549
ENSMUST00000105936 ENSMUSP00000101556
ENSMUST00000105935 ENSMUSP00000101555
ENSMUST00000121128 ENSMUSP00000114076
ENSMUST00000145896 ENSMUSP00000122653
ENSMUST00000143666
ENSMUST00000163148
ENSMUST00000178921 ENSMUSP00000136786
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0030546 receptor activator activity
GO:0043539 protein serine/threonine kinase activator activity
Biological Process
GO:0001649 osteoblast differentiation
GO:0001934 positive regulation of protein phosphorylation
GO:0006006 glucose metabolic process
GO:0007565 female pregnancy
GO:0007613 memory
GO:0009314 response to radiation
GO:0009887 organ morphogenesis
GO:0014070 response to organic cyclic compound
GO:0031017 exocrine pancreas development
GO:0031667 response to nutrient levels
GO:0032355 response to estradiol
GO:0035094 response to nicotine
GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0042060 wound healing
GO:0042104 positive regulation of activated T cell proliferation
GO:0042493 response to drug
GO:0043085 positive regulation of catalytic activity
GO:0043410 positive regulation of MAPK cascade
GO:0045471 response to ethanol
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045840 positive regulation of mitosis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051146 striated muscle cell differentiation
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0071260 cellular response to mechanical stimulus
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090031 positive regulation of steroid hormone biosynthetic process
GO:2000273 positive regulation of receptor activity
GO:2000467 positive regulation of glycogen (starch) synthase activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167244
View Gene Order
ENSBTAG00000013066
Not yet available
Pathways
NETPATH
REACTOME
REACT_230203
Platelet degranulation pathway
REACT_224553
Hemostasis pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_247926
Metabolism of proteins pathway
REACT_235886
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
REACT_188257
Signal Transduction pathway
REACT_188220
SHC-related events triggered by IGF1R pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150139
SHC-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_17015
Metabolism of proteins pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_604
Hemostasis pathway
REACT_202252
Platelet degranulation pathway
REACT_225366
IRS-related events triggered by IGF1R pathway
REACT_206584
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_212196
Hemostasis pathway
REACT_205176
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_216354
IGF1R signaling cascade pathway
REACT_212308
Response to elevated platelet cytosolic Ca2+ pathway
REACT_214353
Signal Transduction pathway
REACT_213782
Metabolism of proteins pathway
REACT_201972
SHC-related events triggered by IGF1R pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.3862 Mm.419447
RefSeq NM_001122736 NM_001122737 NM_010514 XM_006508486 XM_006508487
OMIM
CCDS CCDS22033 CCDS52458
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca