InnateDB Protein
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IDBP-212727.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cdkn1c
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Protein Name
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cyclin-dependent kinase inhibitor 1C (P57)
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Synonyms
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AL024410; CDKI; Kip2; p57(kip2); p57Kip2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000037302
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InnateDB Gene
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IDBG-212725 (Cdkn1c)
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Protein Structure
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Function |
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
18 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004861
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cyclin-dependent protein serine/threonine kinase inhibitor activity
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GO:0005515
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protein binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:104564
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InterPro |
IPR003175
Cyclin-dependent kinase inhibitor
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PFAM |
PF02234
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P49919
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PhosphoSite |
PhosphoSite-P49919
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TrEMBL |
Q791X1
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UniProt Splice Variant |
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Entrez Gene |
12577
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UniGene |
Mm.392059
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RefSeq |
NP_034006
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MGI ID |
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MGI Symbol |
Cdkn1c
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OMIM |
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CCDS |
CCDS22040
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HPRD |
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IMGT |
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EMBL |
AC023248
AF160190
BC005412
CH466531
U20553
U22399
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GenPept |
AAA85096
AAC52186
AAF00983
AAH05412
EDL18207
EDL18208
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