Version 5.4
Mus musculus Gene: Cdkn1c
Summary
InnateDB Gene IDBG-212725.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdkn1c
Gene Name cyclin-dependent kinase inhibitor 1C (P57)
Synonyms AL024410; CDKI; Kip2; p57(kip2); p57Kip2
Species Mus musculus
Ensembl Gene ENSMUSG00000037664
Encoded Proteins
IDBP-212727
cyclin-dependent kinase inhibitor 1C (P57)
IDBP-619953
cyclin-dependent kinase inhibitor 1C (P57)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129757:
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:143458350-143461050
Strand Reverse strand
Band F5
Transcripts
ENSMUST00000037287 ENSMUSP00000037302
ENSMUST00000167912 ENSMUSP00000128828
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001822 kidney development
GO:0001890 placenta development
GO:0007050 cell cycle arrest
GO:0007568 aging
GO:0030099 myeloid cell differentiation
GO:0030325 adrenal gland development
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0033673 negative regulation of kinase activity
GO:0035264 multicellular organism growth
GO:0042326 negative regulation of phosphorylation
GO:0042551 neuron maturation
GO:0043010 camera-type eye development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050680 negative regulation of epithelial cell proliferation
GO:0055123 digestive system development
GO:0060065 uterus development
GO:0060669 embryonic placenta morphogenesis
GO:0071514 genetic imprinting
GO:0071901 negative regulation of protein serine/threonine kinase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000129757
View Gene Order
ENSBTAG00000031184
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04110
Cell cycle pathway
INOH
INOH website
Hedgehog signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04110
Cell cycle pathway
INOH
INOH website
Hedgehog signaling pathway pathway
PID NCI
Cross-References
SwissProt P49919
TrEMBL Q791X1
UniProt Splice Variant
Entrez Gene 12577
UniGene Mm.168789 Mm.392059
RefSeq NM_009876 XM_006508471 NM_001161624
OMIM
CCDS CCDS22040 CCDS52463
HPRD
IMGT
MGI ID MGI:104564
MGI Symbol Cdkn1c
EMBL AC023248 AF160190 BC005412 CH466531 U20553 U22399
GenPept AAA85096 AAC52186 AAF00983 AAH05412 EDL18207 EDL18208
RNA Seq Atlas 12577

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca