InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc22a18

Summary

InnateDB Protein

IDBP-212740.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc22a18

Protein Name

solute carrier family 22 (organic cation transporter), member 18

Synonyms

AW260131; BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2; p45-BWR1A; Slc22a1l; TSSC5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000056082

InnateDB Gene

IDBG-212738 (Slc22a18)

Protein Structure

UniProt Annotation

Function

May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney (By similarity). {ECO:0000250}.

Subcellular Localization

Apical cell membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Note=Localized at the apical membrane surface of renal proximal tubules. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in fetal and adult kidney and liver, and extraembryonic membranes (yolk sac). Expressed at moderate levels in intestine, heart, lung and testis. {ECO:0000269PubMed:9499412, ECO:0000269PubMed:9570947, ECO:0000269PubMed:9802569}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008514	organic anion transmembrane transporter activity
GO:0015238	drug transmembrane transporter activity
GO:0015293	symporter activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006820	anion transport
GO:0006855	drug transmembrane transport
GO:0015711	organic anion transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane

Protein Structure and Domains

PDB ID

MGI:1336884

InterPro

IPR001958 Tetracycline resistance protein, TetA/multidrug resistance protein MdtG
IPR010290 Transmembrane secretion effector
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF05977
PF07690

PRINTS

PR01035

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q78KK3