Mus musculus Gene: Slc22a18
Summary
InnateDB Gene IDBG-212738.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc22a18
Gene Name solute carrier family 22 (organic cation transporter), member 18
Synonyms AW260131; BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2; p45-BWR1A; Slc22a1l; TSSC5;
Species Mus musculus
Ensembl Gene ENSMUSG00000000154
Encoded Proteins
solute carrier family 22 (organic cation transporter), member 18
solute carrier family 22 (organic cation transporter), member 18
solute carrier family 22 (organic cation transporter), member 18
solute carrier family 22 (organic cation transporter), member 18
solute carrier family 22 (organic cation transporter), member 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110628:
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Two alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Oct 2010]
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms\' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Two alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:143473721-143499334
Strand Forward strand
Band F5
Transcripts
ENSMUST00000052348 ENSMUSP00000056082
ENSMUST00000105917 ENSMUSP00000101537
ENSMUST00000146983
ENSMUST00000150791 ENSMUSP00000123047
ENSMUST00000145943 ENSMUSP00000115345
ENSMUST00000141988 ENSMUSP00000120434
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008514 organic anion transmembrane transporter activity
GO:0015238 drug transmembrane transporter activity
GO:0015293 symporter activity
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006820 anion transport
GO:0006855 drug transmembrane transport
GO:0015711 organic anion transport
GO:0015893 drug transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
SLC-mediated transmembrane transport pathway
Transmembrane transport of small molecules pathway
Organic cation/anion/zwitterion transport pathway
Organic cation transport pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Organic cation transport pathway
Organic cation/anion/zwitterion transport pathway
SLC-mediated transmembrane transport pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D6RDC9
UniProt Splice Variant
Entrez Gene 18400
UniGene Mm.271740
RefSeq NM_001042760 NM_008767 XM_006508514 XM_006508515
OMIM
CCDS CCDS22041
HPRD
IMGT
MGI ID MGI:1336884
MGI Symbol Slc22a18
EMBL AC023248
GenPept
RNA Seq Atlas 18400