InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ano1

Summary

InnateDB Protein

IDBP-212923.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ano1

Protein Name

anoctamin 1, calcium activated chloride channel

Synonyms

Tmem16a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033393

InnateDB Gene

IDBG-212921 (Ano1)

Protein Structure

UniProt Annotation

Function

Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. {ECO:0000269PubMed:18585372, ECO:0000269PubMed:18724360, ECO:0000269PubMed:21908539, ECO:0000269PubMed:22002868, ECO:0000269PubMed:22075693}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in pulmonary bronchiole epithelial cells, pancreatic and submandibular gland acinar cells, kidney proximal tubule, all retinal cell layers, most sensory cells of dorsal root ganglia, Leydig cells and spermatocytes (at protein level). Expressed at high levels in the thyroid gland and gastrointestinal muscles. {ECO:0000269PubMed:18585372, ECO:0000269PubMed:18724360, ECO:0000269PubMed:20056604}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005229	intracellular calcium activated chloride channel activity
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006821	chloride transport
GO:0042391	regulation of membrane potential
GO:0060438	trachea development
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016324	apical plasma membrane
GO:0034707	chloride channel complex