InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fmnl1

Summary

InnateDB Protein

IDBP-212978.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fmnl1

Protein Name

formin-like 1

Synonyms

8030453N10Rik; AI553564; Fmnl; Fnrl; Frls;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046296

InnateDB Gene

IDBG-212976 (Fmnl1)

Protein Structure

UniProt Annotation

Function

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. May play a role in the control of cell motility and survival of macrophages. {ECO:0000269PubMed:10958683, ECO:0000269PubMed:21148482}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1.

Disease Associations

Tissue Specificity

Highly expressed in the spleen, lymph node and bone marrow cells. {ECO:0000269PubMed:10958683}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005488	binding
GO:0005515	protein binding
GO:0005522	profilin binding
GO:0017048	Rho GTPase binding
GO:0032794	GTPase activating protein binding
GO:0048365	Rac GTPase binding
GO:0051015	actin filament binding

Biological Process

GO:0006929	substrate-dependent cell migration
GO:0008360	regulation of cell shape
GO:0009987	cellular process
GO:0016043	cellular component organization
GO:0030036	actin cytoskeleton organization
GO:0030866	cortical actin cytoskeleton organization
GO:0051014	actin filament severing