InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cebpb

Summary

InnateDB Protein

IDBP-213092.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cebpb

Protein Name

CCAAT/enhancer binding protein (C/EBP), beta

Synonyms

C/EBPbeta; CRP2; IL-6DBP; LAP; LIP; NF-IL6; NF-M; Nfil6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069850

InnateDB Gene

IDBG-213090 (Cebpb)

Protein Structure

UniProt Annotation

Function

Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Plays an important role in adipose tissue differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG) as well as other adipogenesis key player genes. {ECO:0000269PubMed:19324970, ECO:0000269PubMed:19641492}.Isoform 3: acts as a dominant negative through heterodimerization with isoform 2. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00978, ECO:0000269PubMed:19015024}.

Disease Associations

Tissue Specificity

Abundantly expressed in myoblasts. Enriched in brown adipose tissue (BAT) versus white adipose tissue (WAT). {ECO:0000269PubMed:19641492}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 113 interaction(s) predicted by orthology.

Experimentally validated
Total	71 [view]
Protein-Protein	37 [view]
Protein-DNA	34 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	113 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0035259	glucocorticoid receptor binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001892	embryonic placenta development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0030182	neuron differentiation
GO:0032496	response to lipopolysaccharide
GO:0033598	mammary gland epithelial cell proliferation
GO:0034976	response to endoplasmic reticulum stress
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045408	regulation of interleukin-6 biosynthetic process
GO:0045444	fat cell differentiation
GO:0045600	positive regulation of fat cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050873	brown fat cell differentiation
GO:0060644	mammary gland epithelial cell differentiation
GO:0060850	regulation of transcription involved in cell fate commitment
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0000779	condensed chromosome, centromeric region
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016363	nuclear matrix