InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cebpb

Summary

InnateDB Gene

IDBG-213090.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cebpb

Gene Name

CCAAT/enhancer binding protein (C/EBP), beta

Synonyms

C/EBPbeta; CRP2; IL-6DBP; LAP; LIP; NF-IL6; NF-M; Nfil6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000056501

Encoded Proteins

IDBP-213092

CCAAT/enhancer binding protein (C/EBP), beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21326902

Cebpb is a member of the CCAAT enhancer binding protein family and is a transcriptional factor regulating genes in innate immunity and inflammation. The activities of CEBP are regulated via methylation of arginine and lysine side chains.

PMID 23472114

LPS stimulation promotes the formation of CEBPB complexes on the Serpinb2 promoter to drive transcription.

PMID 24023826

Tnfaip3 is regulated by both Nf-κB and p38-dependent Cebpb in response to LPS in macrophages.

InnateDB Annotation from Orthologs

Summary

PMID 18820298

[Homo sapiens] CEBPB, one of the CEBP family members, is a crucial regulator of gene expression during innate immunity, inflammatory responses and adipogenesis. All of the individual CEBPB isoforms, LAP1, LAP2 and LIP, attenuate EGF-induced PTGS2 (COX-2) promoter activity.

PMID 21326902

[Homo sapiens] CEBPB is a member of the CCAAT enhancer binding protein family and is a transcriptional factor regulating genes in innate immunity and inflammation. The activities of CEBP are regulated via methylation of arginine and lysine side chains.

PMID 24038085

[Homo sapiens] CREB1 and CEBPB are involved in cytokine production in neutrophils in response to LPS and TNF.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172216:
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. [provided by RefSeq, Jul 2008]
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:167688915-167690418

Strand

Forward strand

Band

Transcripts

ENSMUST00000070642

ENSMUSP00000069850

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 113 interaction(s) predicted by orthology.

Experimentally validated
Total	71 [view]
Protein-Protein	37 [view]
Protein-DNA	34 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	113 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0035259	glucocorticoid receptor binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001892	embryonic placenta development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0030182	neuron differentiation
GO:0032496	response to lipopolysaccharide
GO:0033598	mammary gland epithelial cell proliferation
GO:0034976	response to endoplasmic reticulum stress
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045408	regulation of interleukin-6 biosynthetic process
GO:0045444	fat cell differentiation
GO:0045600	positive regulation of fat cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050873	brown fat cell differentiation
GO:0060644	mammary gland epithelial cell differentiation
GO:0060850	regulation of transcription involved in cell fate commitment
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0000779	condensed chromosome, centromeric region
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016363	nuclear matrix