InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nfatc2

Summary

InnateDB Protein

IDBP-213132.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfatc2

Protein Name

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

Synonyms

AI607462; NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074198

InnateDB Gene

IDBG-213130 (Nfatc2)

Protein Structure

UniProt Annotation

Function

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11030334}. Nucleus {ECO:0000269PubMed:11030334}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.

Disease Associations

Tissue Specificity

Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas. {ECO:0000269PubMed:18675896}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	13 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001816	cytokine production
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0010628	positive regulation of gene expression
GO:0016477	cell migration
GO:0030890	positive regulation of B cell proliferation
GO:0042493	response to drug
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050853	B cell receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0030529	ribonucleoprotein complex
GO:0044798	nuclear transcription factor complex

Protein Structure and Domains

PDB ID

MGI:102463

InterPro

IPR002909 IPT domain
IPR008366 Nuclear factor of activated T cells (NFAT)
IPR008967 p53-like transcription factor, DNA-binding
IPR011539 Rel homology domain
IPR014756 Immunoglobulin E-set

PFAM

PF01833
PF00554

PRINTS

PR01789

PIRSF

SMART

SM00429

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt