Version 5.4
Mus musculus Gene: Nfatc2
Summary
InnateDB Gene IDBG-213130.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nfatc2
Gene Name nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
Synonyms AI607462; NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp
Species Mus musculus
Ensembl Gene ENSMUSG00000027544
Encoded Proteins
IDBP-213132
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
IDBP-213138
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
IDBP-262928
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
IDBP-537979
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
IDBP-625049
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20557936
Nfatc2 is a cytokine that acts as an autocrine growth factor during an immune response to bacterial and viral infection, as well as tumorigenesis.
InnateDB Annotation from Orthologs
Summary
PMID 20557936
[Homo sapiens] NFATC2 interacts with JUN to synergistically activate interleukin-2 (IL2) transcription in T cells, a cytokine that acts as an autocrine growth factor during an immune response to bacterial and viral infection, as well as tumourigenesis.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101096:
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:168476410-168601657
Strand Reverse strand
Band H3
Transcripts
ENSMUST00000074618 ENSMUSP00000074198
ENSMUST00000099067
ENSMUST00000029057 ENSMUSP00000029057
ENSMUST00000109184 ENSMUSP00000104812
ENSMUST00000151292
ENSMUST00000137451 ENSMUSP00000118329
ENSMUST00000140137
ENSMUST00000138546
ENSMUST00000171689 ENSMUSP00000130875
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 13 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001816 cytokine production
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0010628 positive regulation of gene expression
GO:0016477 cell migration
GO:0030890 positive regulation of B cell proliferation
GO:0042493 response to drug
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050853 B cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0030529 ribonucleoprotein complex
GO:0044798 nuclear transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101096
View Gene Order
ENSBTAG00000018270
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_230745
Immune System pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_188202
FCERI mediated Ca+2 mobilization pathway
KEGG
mmu04360
Axon guidance pathway
mmu04370
VEGF signaling pathway pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04310
Wnt signaling pathway pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04662
B cell receptor signaling pathway pathway
mmu04380
Osteoclast differentiation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
NetPath_8
Wnt pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
REACTOME
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_6900
Immune System pathway
REACT_163834
FCERI mediated Ca+2 mobilization pathway
KEGG
hsa04370
VEGF signaling pathway pathway
hsa04310
Wnt signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04380
Osteoclast differentiation pathway
INOH
PID NCI
fra_pathway
Validated transcriptional targets of AP1 family members Fra1 and Fra2
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
wnt_noncanonical_pathway
Noncanonical Wnt signaling pathway
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.116802 Mm.415690
RefSeq NM_001037177 NM_001037178 NM_001136073 NM_001291168 NM_001291169 NM_001291170 NM_001291171 NM_001291172 NM_001291173 NM_001291174 NM_001291175 NM_001291176 NM_001291177 NM_001291178 NM_001291179 NM_010899 XM_006498895 XM_006498896
OMIM
CCDS CCDS17112 CCDS17113 CCDS17114 CCDS50803 CCDS71201
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca