InnateDB Protein
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IDBP-213322.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tfap2c
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Protein Name
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transcription factor AP-2, gamma
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Synonyms
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AA409384; Ap-2.2; AP2gamma; Stra2; Tcfap2c;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000030391
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InnateDB Gene
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IDBG-213320 (Tfap2c)
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Protein Structure
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Function |
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in lung, ovary and testis. Expressed in most squamous epithelia. Also, detected in several exocrine glands including the prostate, the preputial and salivary glands, serous glands of the tongue and ocular harderian glands.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
18 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000977
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RNA polymerase II regulatory region sequence-specific DNA binding
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GO:0000980
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RNA polymerase II distal enhancer sequence-specific DNA binding
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GO:0000981
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sequence-specific DNA binding RNA polymerase II transcription factor activity
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GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0001078
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0005515
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protein binding
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GO:0046983
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protein dimerization activity
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0001829
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trophectodermal cell differentiation
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GO:0001942
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hair follicle development
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GO:0003334
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keratinocyte development
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0008584
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male gonad development
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GO:0019827
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stem cell maintenance
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GO:0021877
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forebrain neuron fate commitment
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GO:0021987
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cerebral cortex development
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GO:0030154
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cell differentiation
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GO:0030718
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germ-line stem cell maintenance
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GO:0035019
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somatic stem cell maintenance
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GO:0043588
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skin development
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GO:0045682
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regulation of epidermis development
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0048733
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sebaceous gland development
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GO:0060598
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dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
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GO:0060750
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epithelial cell proliferation involved in mammary gland duct elongation
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Cellular Component |
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PDB ID |
MGI:106032
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InterPro |
IPR008123
Transcription factor AP-2 gamma
IPR013854
Transcription factor AP-2, C-terminal
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PFAM |
PF03299
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PRINTS |
PR01751
PR01748
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q61312
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PhosphoSite |
PhosphoSite-Q61312
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
21420
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UniGene |
Mm.413057
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RefSeq |
NP_033361
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MGI ID |
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MGI Symbol |
Tfap2c
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OMIM |
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CCDS |
CCDS17135
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HPRD |
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IMGT |
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EMBL |
AK145166
AL833787
BC003778
CH466551
X94694
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GenPept |
AAH03778
BAE26271
CAA64357
CAM18031
EDL06609
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