Version 5.4
Mus musculus Gene: Tfap2c
Summary
InnateDB Gene IDBG-213320.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tfap2c
Gene Name transcription factor AP-2, gamma
Synonyms AA409384; Ap-2.2; AP2gamma; Stra2; Tcfap2c
Species Mus musculus
Ensembl Gene ENSMUSG00000028640
Encoded Proteins
IDBP-213322
transcription factor AP-2, gamma
IDBP-213324
transcription factor AP-2, gamma
IDBP-625372
transcription factor AP-2, gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087510:
The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:172549593-172558622
Strand Forward strand
Band H3
Transcripts
ENSMUST00000030391 ENSMUSP00000030391
ENSMUST00000099058 ENSMUSP00000096657
ENSMUST00000128406
ENSMUST00000122982
ENSMUST00000142633
ENSMUST00000170744 ENSMUSP00000129922
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001829 trophectodermal cell differentiation
GO:0001942 hair follicle development
GO:0003334 keratinocyte development
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0008584 male gonad development
GO:0019827 stem cell maintenance
GO:0021877 forebrain neuron fate commitment
GO:0021987 cerebral cortex development
GO:0030154 cell differentiation
GO:0030718 germ-line stem cell maintenance
GO:0035019 somatic stem cell maintenance
GO:0043588 skin development
GO:0045682 regulation of epidermis development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048733 sebaceous gland development
GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000087510
View Gene Order
ENSBTAG00000002065
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.3629 Mm.413057
RefSeq NM_001159696 NM_009335 XM_006499102 XM_006499103 XM_006499104
OMIM
CCDS CCDS17135 CCDS50810
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca