InnateDB Protein
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IDBP-213507.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pecam1
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Protein Name
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platelet/endothelial cell adhesion molecule 1
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Synonyms
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C85791; Cd31; Pecam; PECAM-1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000099358
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InnateDB Gene
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IDBG-213505 (Pecam1)
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Protein Structure
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Function |
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Modulates BDKRB2 activation (By similarity). Induces susceptibility to atherosclerosis. {ECO:0000250, ECO:0000269PubMed:19048083}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform 1 and isoform 3 are expressed in lung and platelets. {ECO:0000269PubMed:18388311}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:97537
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InterPro |
IPR003598
Immunoglobulin subtype 2
IPR003599
Immunoglobulin subtype
IPR007110
Immunoglobulin-like domain
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
SM00408
SM00409
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TIGRFAMs |
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Modification |
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SwissProt |
Q08481
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PhosphoSite |
PhosphoSite-Q08481
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TrEMBL |
B1ARA9
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UniProt Splice Variant |
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Entrez Gene |
18613
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UniGene |
Mm.488284
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RefSeq |
NP_001027550
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MGI ID |
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MGI Symbol |
Pecam1
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OMIM |
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CCDS |
CCDS25558
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HPRD |
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IMGT |
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EMBL |
AK169431
AL603664
BC008519
BC085502
CH466558
L06039
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GenPept |
AAA16230
AAH08519
AAH85502
BAE41172
CAM18558
CAM18559
CAM18560
EDL34303
EDL34304
EDL34305
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