InnateDB Protein
|
IDBP-21398.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
DAZL
|
Protein Name
|
deleted in azoospermia-like
|
Synonyms
|
DAZH; DAZL1; DAZLA; SPGYLA;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000250863
|
InnateDB Gene
|
IDBG-21396 (DAZL)
|
Protein Structure
|
|
Function |
RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Testis specific. {ECO:0000269PubMed:8896558, ECO:0000269PubMed:8968755, ECO:0000269PubMed:8968756}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
6
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
4 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000504
RNA recognition motif domain
|
PFAM |
PF00076
|
PRINTS |
|
PIRSF |
|
SMART |
SM00360
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q92904
|
PhosphoSite |
PhosphoSite-Q92904
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
1618
|
UniGene |
Hs.613297
|
RefSeq |
NP_001177740
|
HUGO |
HGNC:2685
|
OMIM |
601486
|
CCDS |
CCDS54556
|
HPRD |
09029
|
IMGT |
|
EMBL |
AC010139
AK303026
BC027595
BX648638
CH471055
U65918
U66078
U66726
U77467
U77468
U77469
U77470
U77471
U77472
U77473
U77474
U77475
U77476
|
GenPept |
AAB39935
AAB63596
AAB84361
AAC50813
AAH27595
BAG64152
CAI45996
EAW64279
|
|
|