Mus musculus Protein: Rtel1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-214072.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Rtel1 | ||||||||||||||||||||||
Protein Name | regulator of telomere elongation helicase 1 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000053120 | ||||||||||||||||||||||
InnateDB Gene | IDBG-214068 (Rtel1) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. {ECO:0000255HAMAP- Rule:MF_03065, ECO:0000269PubMed:15210109, ECO:0000269PubMed:22579284, ECO:0000269PubMed:22593209, ECO:0000269PubMed:24115439}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000255HAMAP-Rule:MF_03065, ECO:0000269PubMed:15210109, ECO:0000269PubMed:24115439}. Note=Colocalizes with PCNA within the replication foci in S-phase cells. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Widely expressed. Expressed in spleen, thymus, Peyer patches, kidney, and intestine. Not expressed in brain, heart, lung, skeletal muscles, skin and white fat. In the adult gonad, it is highly expressed in the testis, mainly in the spermatogonia and meiotic spermatocytes. {ECO:0000269PubMed:15210109}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:2139369 | ||||||||||||||||||||||
InterPro |
IPR006554
Helicase-like, DEXD box c2 type IPR006555 ATP-dependent helicase, C-terminal IPR010614 DEAD2 IPR013020 DNA helicase (DNA repair), Rad3 type IPR014013 Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF13307
PF06733 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00488
SM00491 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q0VGM9 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q0VGM9 | ||||||||||||||||||||||
TrEMBL | Q5F0J9 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 269400 | ||||||||||||||||||||||
UniGene | Mm.488418 | ||||||||||||||||||||||
RefSeq | NP_001001882 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Rtel1 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS17208 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AK145145 AK173097 AL928965 AY481618 AY481619 AY481620 AY481621 AY481622 AY481623 BC105578 BC144977 BC144978 BC145658 | ||||||||||||||||||||||
GenPept | AAI05579 AAI44978 AAI44979 AAI45659 AAR27233 AAR27234 AAR27235 AAR27236 AAR27237 AAR27238 BAD32375 BAE26258 CAM26413 CAM26414 CAM26415 CAM26416 CAM26417 CAM26418 | ||||||||||||||||||||||