InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prpf6

Summary

InnateDB Protein

IDBP-214172.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prpf6

Protein Name

PRP6 pre-mRNA splicing factor 6 homolog (yeast)

Synonyms

1190003A07Rik; 2610031L17Rik; ANT-1; U5-102K;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002529

InnateDB Gene

IDBG-214170 (Prpf6)

Protein Structure

UniProt Annotation

Function

Involved in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. {ECO:0000250}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000250}. Nucleus speckle {ECO:0000250}. Note=Localized in splicing speckles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0043021	ribonucleoprotein complex binding
GO:0044822	poly(A) RNA binding
GO:0050681	androgen receptor binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006396	RNA processing
GO:0006403	RNA localization
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005682	U5 snRNP
GO:0016020	membrane
GO:0016607	nuclear speck
GO:0046540	U4/U6 x U5 tri-snRNP complex
GO:0071001	U4/U6 snRNP
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

MGI:1922946

InterPro

IPR003107 RNA-processing protein, HAT helix
IPR010491 PRP1 splicing factor, N-terminal
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat

PFAM

PF02184
PF06424
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00386
SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91YR7