InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Prpf6

Summary

InnateDB Gene

IDBG-214170.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prpf6

Gene Name

PRP6 pre-mRNA splicing factor 6 homolog (yeast)

Synonyms

1190003A07Rik; 2610031L17Rik; ANT-1; U5-102K

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002455

Encoded Proteins

IDBP-214172

PRP6 pre-mRNA splicing factor 6 homolog (yeast)

IDBP-542928

PRP6 pre-mRNA splicing factor 6 homolog (yeast)

IDBP-542929

PRP6 pre-mRNA splicing factor 6 homolog (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101161:
The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:181591868-181655660

Strand

Forward strand

Band

Transcripts

ENSMUST00000002529	ENSMUSP00000002529
ENSMUST00000132714	ENSMUSP00000117711
ENSMUST00000136481	ENSMUSP00000121340
ENSMUST00000139955

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0043021	ribonucleoprotein complex binding
GO:0044822	poly(A) RNA binding
GO:0050681	androgen receptor binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006396	RNA processing
GO:0006403	RNA localization
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005682	U5 snRNP
GO:0016020	membrane
GO:0016607	nuclear speck
GO:0046540	U4/U6 x U5 tri-snRNP complex
GO:0071001	U4/U6 snRNP
GO:0071013	catalytic step 2 spliceosome