InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALOX5AP

Summary

InnateDB Protein

IDBP-21440.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALOX5AP

Protein Name

arachidonate 5-lipoxygenase-activating protein

Synonyms

FLAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000369858

InnateDB Gene

IDBG-21438 (ALOX5AP)

Protein Structure

UniProt Annotation

Function

Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. {ECO:0000269PubMed:2300173, ECO:0000269PubMed:8440384}.

Subcellular Localization

Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition. {ECO:0000269PubMed:14770184, ECO:0000269PubMed:17304054}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	4 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0047485	protein N-terminus binding
GO:0050544	arachidonic acid binding

Biological Process

GO:0006691	leukotriene metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019370	leukotriene biosynthetic process
GO:0019372	lipoxygenase pathway
GO:0043085	positive regulation of catalytic activity
GO:0044281	small molecule metabolic process
GO:0070207	protein homotrimerization
GO:0071277	cellular response to calcium ion
GO:2001300	lipoxin metabolic process

Cellular Component

GO:0005635	nuclear envelope
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane