Mus musculus Protein: Hgs | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-214823.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Hgs | ||||||||||||||||||||||
Protein Name | HGF-regulated tyrosine kinase substrate | ||||||||||||||||||||||
Synonyms | Hgr; Hrs; ZFYVE8; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000026900 | ||||||||||||||||||||||
InnateDB Gene | IDBG-214821 (Hgs) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. {ECO:0000269PubMed:11094085}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome, multivesicular body membrane; Peripheral membrane protein. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Ubiquitous expression in adult and fetal tissues with higher expression in testis. {ECO:0000269PubMed:7565774, ECO:0000269PubMed:9630564}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 138 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:104681 | ||||||||||||||||||||||
InterPro |
IPR000306
FYVE zinc finger IPR002014 VHS IPR003903 Ubiquitin interacting motif IPR008942 ENTH/VHS IPR011011 Zinc finger, FYVE/PHD-type IPR017073 Ubiquitin binding protein, Hrs/VPS27 IPR017455 Zinc finger, FYVE-related IPR018205 VHS subgroup IPR024641 Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain |
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PFAM |
PF01363
PF00790 PF02809 PF12210 |
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PRINTS | |||||||||||||||||||||||
PIRSF |
PIRSF036956
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SMART |
SM00064
SM00726 SM00288 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q99LI8 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q99LI8 | ||||||||||||||||||||||
TrEMBL | Q3UMA3 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 15239 | ||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NP_032270 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Hgs | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS49005 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AK046299 AK145031 AL669855 BC003239 D50050 | ||||||||||||||||||||||
GenPept | AAH03239 BAA08768 BAC32676 BAE26195 | ||||||||||||||||||||||