Mus musculus Gene: Hgs
Summary
InnateDB Gene IDBG-214821.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hgs
Gene Name HGF-regulated tyrosine kinase substrate
Synonyms Hgr; Hrs; ZFYVE8;
Species Mus musculus
Ensembl Gene ENSMUSG00000025793
Encoded Proteins
HGF-regulated tyrosine kinase substrate
HGF-regulated tyrosine kinase substrate
HGF-regulated tyrosine kinase substrate
HGF-regulated tyrosine kinase substrate
HGF-regulated tyrosine kinase substrate
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185359:
The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:120467635-120483984
Strand Forward strand
Band E2
Transcripts
ENSMUST00000026900 ENSMUSP00000026900
ENSMUST00000106205 ENSMUSP00000101811
ENSMUST00000106203 ENSMUSP00000101809
ENSMUST00000141826
ENSMUST00000140862 ENSMUSP00000119396
ENSMUST00000135231 ENSMUSP00000115037
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 138 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 138 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0046872 metal ion binding
Biological Process
GO:0006886 intracellular protein transport
GO:0008333 endosome to lysosome transport
GO:0046426 negative regulation of JAK-STAT cascade
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0030141 secretory granule
GO:0031901 early endosome membrane
GO:0032585 multivesicular body membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
EGFR downregulation pathway
Disease pathway
Membrane Trafficking pathway
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
Signaling by EGFR pathway
Signal Transduction pathway
Signaling by EGFR in Cancer pathway
KEGG
Endocytosis pathway
Phagosome pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
TGF_beta_Receptor pathway
TCR pathway
REACTOME
Signaling by EGFR in Cancer pathway
Signaling by EGFR pathway
Signal Transduction pathway
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
EGFR downregulation pathway
Disease pathway
Membrane Trafficking pathway
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
Signaling by EGFR pathway
Signal Transduction pathway
Signaling by EGFR in Cancer pathway
EGFR downregulation pathway
Disease pathway
Membrane Trafficking pathway
KEGG
Endocytosis pathway
Phagosome pathway
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
CXCR4-mediated signaling events
Internalization of ErbB1
Signaling events mediated by VEGFR1 and VEGFR2
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 15239
UniGene
RefSeq NM_001159328 NM_008244 XM_006532274
OMIM
CCDS CCDS49005
HPRD
IMGT
MGI ID MGI:104681
MGI Symbol Hgs
EMBL
GenPept
RNA Seq Atlas 15239