InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: P4hb

Summary

InnateDB Protein

IDBP-214841.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P4hb

Protein Name

prolyl 4-hydroxylase, beta polypeptide

Synonyms

ERp59; PDI; Pdia1; Thbp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026122

InnateDB Gene

IDBG-214839 (P4hb)

Protein Structure

UniProt Annotation

Function

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138}. Melanosome {ECO:0000250}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources. Localizes near CD4-enriched regions on lymphoid cell surfaces (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	58 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0004656	procollagen-proline 4-dioxygenase activity
GO:0005515	protein binding
GO:0016853	isomerase activity
GO:0019899	enzyme binding
GO:0031545	peptidyl-proline 4-dioxygenase activity
GO:0044822	poly(A) RNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006457	protein folding
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0034976	response to endoplasmic reticulum stress
GO:0045454	cell redox homeostasis
GO:0071456	cellular response to hypoxia
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005886	plasma membrane
GO:0016222	procollagen-proline 4-dioxygenase complex
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome